Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. Myasthenia gravis (MG) is a T cell dependent and antibody mediated autoimmune disease. Although it has been shown that complement plays a critical role in the pathogenesis of MS, GBS, and MG, the role of mannose-binding lectin (MBL) as a biomarker of immunopathogensis of these diseases and also its association with the severity of them have been poorly investigated. Therefore, in this study we aimed to measure plasma levels of MBL in patients with MS, GBS, and MG.In a case-control study, plasma was obtained from healthy controls (n=100) and also patients with MS (n=120), GBS (n=30), and MG (n=30). Plasma level measurement of MBL was performed using enzyme-linked immunosorbent assay (ELISA).The mean serum level of MBL was significantly different between groups of patients and healthy controls (p<0.001). We also found a positive correlation between plasma levels of MBL and severity scores of MS, MG, and GBS patients including: expanded disability status scale (EDSS) (r=+0.60 and p=<0.001), quantitative myasthenia gravis score (QMGS) (r=+0.56 and p=0.01), and GBS disability scale (GDS) (r=+0.37 and p=0.04).Taken together, our findings suggest that complement activation mediated by MBL contributes to the pathogenesis and also severity of MS, MG, and GBS. However, because the lectin pathway can be involved in several phases of the immune response, further evidence will be required to elucidate the underlying mechanism.

Background: Primary complement deficiencies are rare diseases. Objective: To retrospectively evaluate the clinical and laboratory findings and complications of patients to increase awareness of pediatricians about complement deficiencies, which are rarely encountered. Methods: In this study, the clinical and immunological characteristics of 21 patients who consulted the Immunology Department of our hospital between 2003 and 2017 and were diagnosed with classical or alternative pathway complement deficiency were obtained from the file records. Results: Ten patients with C1 inhibitor deficiency, four patients with factor I deficiency, three patients with properdin deficiency, two patients with C8 deficiency, one patient with C1q deficiency, and one patient with C4B deficiency were assessed. The mean age of the patients at diagnosis was 11. 4± 4. 7 years, the age of onset of symptoms was 7. 9± 3. 9 years, and the follow-up period was 6. 7± 3. 9 years. Fourteen cases had a similar medical history in the family. All patients with C1q, factor I, properdin, C8, and C4B deficiencies presented with an infection, and vasculitic rash was present in two patients with factor I deficiency. In addition, immune complex glomerulonephritis was present in one patient with factor I deficiency. Meningococcal, Haemophilus influenzae type B, and pneumococcal vaccines were administered and prophylactic antibiotic treatment was initiated in all patients except patients with C1 inhibitor deficiency. Conclusions: Early diagnosis of complement deficiencies can facilitate prevention of life-threatening complications such as severe bacterial infections by considering prophylactic antibiotics and vaccines. In patients with C1 inhibitor deficiency, achieving an acurate early diagnosis will assist in the management and timely treatment of life-threatening attacks such as upper airway obstruction and improve outcomes.

complement C3 glomerulopathy refers to a disease process in which abnormal control of complement activation or degradation results in predominant C3 fragment deposition within the glomerulus and causes glomerular damage. Abnormal control of the complement alternative pathway is a well-established risk factor for the occurrence of C3 glomerulonephritis. It is the first reported case in Iran with multiple mutations in complement factor H, with one of these mutations we have expected in hemolytic uremic syndrome rather than C3 glomerulopathy. Genetic analysis showed that the molecular abnormalities of factor H led to complement factor H malfunction that were polymorphous and not restricted to the C-terminal domains of the protein.

One of the issues of reliable performance in the power grid is the existence of electromechanical oscillations between interconnected generators. The number of generators participating in each electromechanical oscillation mode and the frequency oscillation depends on the structure and function of the power grid. In this paper, to improve the transient nature of the network and damping electromechanical fluctuations, a decentralized robust adaptive control method based on dynamic programming has been used to design a stabilizing power system and a complementary static var compensator (SVC) controller. By applying a single line to ground fault in the network, the robustness of the designed control systems is demonstrated. Also, the simulation results of the method used in this paper are compared with controllers whose parameters are adjusted using the PSO algorithm. The simulation results show the superiority of the decentralized robust adaptive control method based on dynamic programming for the stabilizing design of the power system and the complementary SVC controller. The performance of the control method is tested using the IEEE 16-machine, 68-bus, 5-area is verified with time domain simulation.

In this article, the Zariski topology is extended as the Zariski-countable topology. This imposes a new kind of manifolds using the countable-complement topology that the algebraic varieties are the analytic case of them. The advantage of this work is to convert any non-countable field to a topological field by Zariski-countable topology. This conversion is not possible by the usual Zariski topology.

Object complement construction as one of the most important and challenging categories of grammar has been noticed by linguists and grammarians from past to present. The present study investigates the Object complement construction based on three basic hypotheses: Small Clause Theory, Predication Theory, and Complex Predicate Theory. Most of the linguists and grammarians who have studied Object complement construction in the Persian language have presented a similar view of the Predication theory. The findings of this study revealed that the analysis of the Object complement construction within the framework of Predication Theory is incompatible with the principles of the Government and Binding theory and Minimalist Program, such as the Theta criterion, Projection principle, and Uniformity of Theta Assignment Hypothesis (UTAH). The analysis of the mentioned construction based on the complex predicate theory on the one hand ignores the principle of linguistic economy and productivity process by increasing the number of compound verbs in Persian, and on the other hand, it ignores the propositional relationship between the Object complement construction and the preceding noun phrase. In the following, based on small clause theory and arguments such as argument alternation, selection restriction, the ambiguity of the interrogative complex sentences, occurrence in different syntactic contexts, idiom chunk, agreement, paraphrasing, sentence fragment, scrambling, gapping pronominalization,  and the distribution of NP-types as subjects of small clause construction was shown Object complement together with the preceding noun phrase should be considered a single constituent as a small clause.